Spectacular rejuvenation of untimely aged mice clues at possible therapy

Immature aging can be overturned by reactivating an enzyme that protects the tips of chromosomes, a research in mice evokes.

Men of science led by Ronald A. DePinho (above), a Harvard school of medicine professor of genetic science, say their study demonstrates for the 1st time a spectacular reversion of many facets of age-related degeneration in mice, a milestone in aging scientific discipline accomplished by engineering mice with a manageable telomerase gene.

Mice orchestrated to lack the enzyme, called telomerase, convert prematurely weak. But they recovered to wellness when the enzyme was replaced. The study, brought out online November 28 in Nature, clues that some conditions characterised by early aging could be handled by boosting telomerase activity.

This study can be the best option for normal human aging to be decelerated by reawakening the enzyme in cells where it has stopped working, says Ronald DePinho, a malignant neoplastic disease geneticist at the Dana-Farber Cancer Institute and Harvard Medical School in Boston, Massachusetts, who chaired the new study. "This has implications for thinking about telomerase as a serious anti-aging intervention."

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